Search on: CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6 
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Descriptor English:   Cyclic Nucleotide Phosphodiesterases, Type 6 
Descriptor Spanish:   Fosfodiesterasas de Nucleótidos Cíclicos Tipo 6 
Descriptor Portuguese:   Nucleotídeo Cíclico Fosfodiesterase do Tipo 6 
Synonyms English:   Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit
Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit
PDE6 Phosphodiesterases
PDE6, alpha Subunit
PDE6, beta Subunit
PDE6, delta Subunit
Phosphodiesterase 6
Phosphodiesterase Type 6
Retinal Phosphodiesterase 6
Retinal Phosphodiesterase, alpha Subunit
Retinal Phosphodiesterase, beta Subunit
Retinal Phosphodiesterase, delta Subunit
Rod cGMP Phosphodiesterase, beta Subunit
alpha Subunit, PDE6
beta Subunit, PDE6
cGMP Phosphodiesterase delta Subunit
cGMP-PDE gamma Subunit
delta Subunit, PDE6
gamma Subunit, cGMP Phosphodiesterase
PDE6 alpha Subunit
PDE6 beta Subunit
PDE6 delta Subunit
Phosphodiesterase 6, Retinal
Phosphodiesterases, PDE6
alpha Subunit PDE6
beta Subunit PDE6
cGMP PDE gamma Subunit
delta Subunit PDE6
gamma Subunit, cGMP-PDE  
Tree Number:   D08.811.277.352.640.150.600
D08.811.277.352.640.155.750
D12.644.360.008.600
D12.644.360.009.750
D12.776.476.008.600
D12.776.476.009.750
Definition English:   A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme. 
History Note English:   2008(2001) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   52681 
Unique Identifier:   D054707 

Occurrence in VHL: 		 

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